TOPLINE:Children of mothers who had obesity or eating disorders before or during pregnancy may face higher risks for neurodevelopmental and psychiatric disorders.
METHODOLOGY:Researchers conducted a population-based cohort study to investigate the association of maternal eating disorders and high prepregnancy body mass index (BMI) with psychiatric disorder and neurodevelopmental diagnoses in offspring.They used Finnish national registers to assess all live births from 2004 through 2014, with follow-up until 2021.Data of 392,098 mothers (mean age, 30.15 years) and 649,956 offspring (48.86% girls) were included.Maternal eating disorders and prepregnancy BMI were the main exposures, with 1.60% of mothers having a history of eating disorders; 5.89% were underweight and 53.13% had obesity.Diagnoses of children were identified and grouped by ICD-10 codes of mental, behavioral, and neurodevelopmental disorders, mood disorders, anxiety disorders, sleep disorders, attention-deficit/hyperactivity disorder, and conduct disorders, among several others.TAKEAWAY:From birth until 7-17 years of age, 16.43% of offspring were diagnosed with a neurodevelopmental or psychiatric disorder.Maternal eating disorders were associated with psychiatric disorders in the offspring, with the largest effect sizes observed for sleep disorders (hazard ratio [HR], 2.36) and social functioning and tic disorders (HR, 2.18; P <.001 for both offspring of mothers with severe prepregnancy obesity had a more than twofold increased risk intellectual disabilities ci being underweight before pregnancy was also linked to many psychiatric disorders in offspring.the occurrence adverse birth outcomes along maternal eating or high bmi further the neurodevelopmental and offspring.in practice: findings underline mental illness associated suggest need consider these exposures clinically help prevent authors wrote. source:this study led by ida a.k. nilsson phd department molecular medicine surgery at karolinska institutet stockholm sweden published online on october jama network open. limitations:a limitation relatively short follow-up time which restricted inclusion late-onset disorder diagnoses such as schizophrenia spectrum disorders. paternal data genetic information may have influenced interpretation were not available. another potential bias that been perceptive their child behavior leading greater access care diagnosis children. disclosures:this work supported swedish research council regional agreement medical training clinical between region brain foundation other sources. declared no conflicts interest. this article created using several editorial tools including ai part process. human editors reviewed content publication.>
Source : Medscape