Enforced CARD11/MALT1 signaling in dendritic cells triggers hemophagocytic lymphohistiocytosis

Proceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024.
SignificanceHemophagocytic lymphohistiocytosis (HLH) is a life-threatening immunopathology with high mortality and poorly understood mechanisms. Our study is based on clinical observations that patients with germline gain-of-function (GOF) mutations in …
Source : National Academy of Sciences