TOPLINE:Older adults with celiac disease (CeD) face a higher risk of developing frailty within 5 years than those without the condition, a finding that indicates the need for targeted interventions.
METHODOLOGY:Researchers used data from Swedish healthcare registries to a conduct nationwide retrospective cohort study that investigated the risk for frailty and its prevalence between 2004 and 2017.They matched 4646 people aged 60 years or older diagnosed with CeD (mean age at diagnosis, 71 years; 52% women) with 21,944 control individuals without the condition. Additionally, siblings of individuals with CeD were identified through registry linkage as secondary controls.Researchers assessed frailty at baseline, defined as within 3 years before diagnosis or index date, using the Hospital Frailty Risk Score (HFRS) and at 1, 3, and 5 years post-diagnosis. A score of 0 is classified as no risk,> 0-4 is low risk, 5-15 is intermediate risk, and> 15 is high risk.Further analysis compared the risk for frailty between patients with CeD who achieved mucosal healing (n=530) and those with persistent villous atrophy (n=447), as determined by follow-up biopsy.TAKEAWAY:At baseline, frailty (HFRS ≥ 1) was present in 54.4% of older adults with CeD, compared with only 29.7% of matched controls (odds ratio [OR], 2.91; P <.001 patients who were not frail at baseline an increased risk for frailty> 0) at 5 years was seen in 53.6% of patients with CeD, compared with 41.1% of controls. The risk for high-risk frailty was substantially elevated in patients with CeD, particularly in women.Those with CeD also exhibited a higher risk for frailty than their siblings without the condition (adjusted OR, 1.73; P <.001 risk for frailty did not differ between those with ced who achieved mucosal healing and persistent villous atrophy.in practice: patients disease may a particularly vulnerable group benefit from targeted frailty-related management dedicated gastroenterology nutrition services the authors wrote. identifying have providers be able to develop more interventions in of older adults ced. source:the study led by haley m. zylberberg md columbia university college physicians surgeons new york city was published online american journal gastroenterology. limitations:the small sample size high-risk limited reliability interpretations specific categories. data on factors influencing including alcohol consumption smoking status mental health history osteoporosis were available. retrospective design restricted inclusion serological diagnosis inability assess adherence gluten-free diet affected evaluation healing. disclosures:one author disclosed coordinating funded pharmaceutical company receiving financial support biopharmaceutical paper having an ongoing collaboration another reported through program company. grant national institute aging companies that had ended time this conducted. article created using several editorial tools ai as part process. human editors reviewed content before publication.>
Source : Medscape