TOPLINE:Older adults with celiac disease (CeD) face a higher risk of developing frailty within 5 years than those without the condition, a finding that indicates the need for targeted interventions.
METHODOLOGY:Researchers used data from Swedish healthcare registries to a conduct nationwide retrospective cohort study that investigated the risk for frailty and its prevalence between 2004 and 2017.They matched 4646 people aged 60 years or older diagnosed with CeD (mean age at diagnosis, 71 years; 52% women) with 21,944 control individuals without the condition. Additionally, siblings of individuals with CeD were identified through registry linkage as secondary controls.Researchers assessed frailty at baseline, defined as within 3 years before diagnosis or index date, using the Hospital Frailty Risk Score (HFRS) and at 1, 3, and 5 years post-diagnosis. A score of 0 is classified as no risk,> 0-4 is low risk, 5-15 is intermediate risk, and> 15 is high risk.Further analysis compared the risk for frailty between patients with CeD who achieved mucosal healing (n=530) and those with persistent villous atrophy (n=447), as determined by follow-up biopsy.TAKEAWAY:At baseline, frailty (HFRS ≥ 1) was present in 54.4% of older adults with CeD, compared with only 29.7% of matched controls (odds ratio [OR], 2.91; P 0) at 5 years was seen in 53.6% of patients with CeD, compared with 41.1% of controls. The risk for high-risk frailty was substantially elevated in patients with CeD, particularly in women.Those with CeD also exhibited a higher risk for frailty than their siblings without the condition (adjusted OR, 1.73; P
Source : Medscape