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Sit Less, Move More for Heart Health

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A new analysis using data from the Prospective Urban Rural Epidemiology (PURE) study shows that sitting more than 8 hours per day was associated with an increased risk of a composite of all-cause death and cardiovascular disease (CVD) events.

In this study that tracked over 100,000 adults from 21 countries for 8 to 12 years, more time spent sitting during the day was associated with increased risk of early death and CVD events, including cardiovascular death, myocardial infarction (MI), stroke, or heart failure.

The combination of prolonged sitting and physical inactivity was particularly harmful, accounting for nearly 9% of all deaths.

“This is close to the contribution of smoking (10.6% in our study),” Scott Lear, PhD, with Simon Fraser University, Vancouver, British Columbia, told theheart.org | Medscape Cardiology. Importantly, the increased risks of prolonged sitting were offset by increased physical activity, he said.

The observation held across the economically diverse settings in this study and was even more pronounced in lower- and lower-middle-income countries, they note. “Reducing sedentary time and along with increasing physical activity might be an important strategy for easing the global burden of premature deaths and CVD,” the authors conclude.

The study was published online June 15 in JAMA Cardiology.

The findings are based on data from 105,677 adults aged 35 to 70 years (mean age, 50 years; 59% women) from the PURE cohort. During a median follow-up of 11 years, there were 6233 deaths and 5696 major CVD events.

In multivariable adjusted models, compared to those who sat for fewer than 4 hours per day, those who sat for 8 or more hours per day had a 20% higher risk for all-cause death (hazard ratio [HR], 1.20; 95% CI, 1.1 – 1.31; P for trend <.001 and a higher risk for major cvd ci p trend sitting to hours per day was associated with increased death the association held high- middle- low-income countries but stronger in lower-middle-income countries. can only speculate why it may be due socioeconomic factors such that high-income is more higher-paid jobs status lear said. you must sit getting exercise at other times during help offset risks he noted. study those who sat were least active had highest greater contrast most lowest risk. important clinicians realize scope of problem how substantially physical inactivity contribute disease told theheart.org medscape cardiology. encourages focus on intervention promoting activity reducing time. too should take these findings heart ensure they are following guidelines maintaining their health reached comment harlan krumholz md yale new haven hospital school medicine connecticut said challenging make causal inferences from observational data this well-done massive diverse population. sedentary behavior adverse outcomes plausible solution has little downside much upside our society increasingly drifts toward screen time less we need consider what effects might have long-term function seem built move suffer if do not. article certainly supports my bias encouraging people stay as way promote lifelong added. pure funded by population research institute hamilton sciences canadian institutes stroke foundation ontario strategy patient oriented through spor support unit ministry care unrestricted grants astrazeneca sanofi-aventis canada boehringer ingelheim servier glaxosmithkline additional contributions novartis king pharma various national or local organizations participating disclosed no relevant financial relationships. jama cardiol. published online june abstract news follow facebook twitter instagram youtube.>
Source : Medscape

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