Adults with high cholesterol taking statins may have a significantly higher risk of developing glaucoma than those not taking the cholesterol-lowering drugs, an observational study of a large research database found.
The study, published in Ophthalmology Glaucoma, analyzed electronic health records of 79,742 adults with hyperlipidemia in the All of Us Research Program database from 2017 to 2022. The repository is maintained by the National Institutes of Health and provides data for research into precision medicine.
The 6365 statin users in the study population had a 47% greater unadjusted prevalence of glaucoma than nonusers of the drugs (P <.001 and a greater prevalence in models that adjusted for potential confounding variables the researchers also found statin users had significantly higher levels of low-density lipoprotein cholesterol but even patients with optimal ldl-c rates glaucoma. little unusual tseng mddrawing any clinically relevant conclusions from this latest study would be premature victoria md phd an assistant professor at ucla stein eye institute doheny centers senior author said. certainly not telling my on statins to stop their acknowledged her group finding runs counter previous studies may help prevent glaucoma or least have no effect disease although association between has been well established she added. analysis nearly participants three population connection use risk primary open-angle more than people high was associated significant reduction we opposite told medscape medical news. one explanation is observational nature aou conducted. don know what these look like how data were collected so going off there database another could hyperlipidemia itself definitely suggest increased are you taking unless your worse. while attempted control noted some residual that. average level mg vs medication>
Source : Medscape