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HomeScience and NatureCleavage-independent activation of ancient eukaryotic gasdermins and structural mechanisms | Science

Cleavage-independent activation of ancient eukaryotic gasdermins and structural mechanisms | Science

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Gasdermins (GSDMs) are pore-forming proteins that execute pyroptosis for immune defense. GSDMs are two-domain proteins activated by proteolytic removal of the inhibitory domain. In this work, we report two types of cleavage-independent GSDM activation. …
Source : ScienceMag

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