Co-option of mitochondrial nucleic acid–sensing pathways by HSV-1 UL12.5 for reactivation from latent infection

Proceedings of the National Academy of Sciences, Volume 122, Issue 4, January 2025.
SignificanceHerpes simplex virus-1 (HSV-1) persists as a latent infection of neurons and reactivates to cause disease. Understanding host pathways required for reactivation is crucial to developing therapeutics. The HSV-1 protein, UL12.5, activates …
Source : National Academy of Sciences