Crucial role of the cGAS N terminus in mediating flowable and functional cGAS–DNA condensate formation via DNA interactions

Proceedings of the National Academy of Sciences, Volume 122, Issue 3, January 2025.
SignificancecGAS, an essential innate immune sensor of DNA, is implicated in various diseases. We identified that the N-terminal intrinsic disordered region of cGAS, cGASNterm, regulates the enzymatic activity of the cGAS condensates by modulating its …
Source : National Academy of Sciences