Direct lysine dimethylation of IRF3 by the methyltransferase SMYD3 attenuates antiviral innate immunity

Proceedings of the National Academy of Sciences, Volume 122, Issue 3, January 2025.
SignificanceAs a key factor in the type I interferon signaling, Interferon regulatory factor 3 (IRF3) activation must be tightly controlled to efficiently activate innate immunity and avoid overactivation of innate immunity. However, how the IRF3 …
Source : National Academy of Sciences