Early disruption of the CREB pathway drives dendritic morphological alterations in FTD/ALS cortical neurons

Proceedings of the National Academy of Sciences, Volume 121, Issue 49, December 2024.
SignificanceThe cAMP-dependent transcription factor CREB is essential to sustain neuronal function and health. One important process modulated by CREB is dendritic branching and synapse formation. Synapse loss is a common cellular pathology in several …
Source : National Academy of Sciences