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HomeScience and NatureExposed Hsp70-binding site impacts yeast Sup35 prion disaggregation and propagation

Exposed Hsp70-binding site impacts yeast Sup35 prion disaggregation and propagation

by News7

Proceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024.
SignificanceMany neurodegenerative diseases are associated with formation of β-sheet-rich fibrillar protein aggregates called amyloids. Importantly, amyloids can be disaggregated by multiple chaperones in cells, which potentially impacts cellular …
Source : National Academy of Sciences

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