Hapalindole Q suppresses autophagosome−lysosome fusion by promoting YAP1 degradation via chaperon-mediated autophagy

Proceedings of the National Academy of Sciences, Volume 121, Issue 50, December 2024.
SignificanceTargeting autophagy has shown increasing promise in the treatment of various diseases. While exploring the biological functions of indole terpenoids, we identified hapalindole Q as a mechanistically intriguing macroautophagy inhibitor, which …
Source : National Academy of Sciences