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Home Science and Nature Heterogeneous and multiple conformational transition pathways between pseudoknots of the SARS-CoV-2 frameshift element

Heterogeneous and multiple conformational transition pathways between pseudoknots of the SARS-CoV-2 frameshift element

by Miles Cooper

Proceedings of the National Academy of Sciences, Volume 122, Issue 4, January 2025.
SignificanceFrameshifting is an essential viral replication mechanism for compact RNA genomes. For SARS-CoV-2, a specific 3-stem RNA pseudoknot has been identified to stimulate frameshifting, but other folds have been suggested. Here, we capture atomic…
Source : National Academy of Sciences

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