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HomeScience and NatureIon permeation through a narrow cavity constriction in KCNQ1 channels: Mechanism and implications for pathogenic variants

Ion permeation through a narrow cavity constriction in KCNQ1 channels: Mechanism and implications for pathogenic variants

by News7

Proceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024.
SignificanceThe latest atomic resolution structures of KCNQ channels feature a narrow cavity region not sufficiently wide to accommodate fully hydrated K+ions. The mechanism of K+permeation through this constriction and the functional impact of the …
Source : National Academy of Sciences

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