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HomeScience and NatureLeukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosis

Leukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosis

by News7

Proceedings of the National Academy of Sciences, Volume 121, Issue 50, December 2024.
SignificanceFibroblasts have a central role in the pathogenesis of fibrotic diseases. However, targeting a single activator of fibroblasts, like TGFβ, has failed in clinical trials, likely due to the existence of multiple, upstream profibrotic stimuli…
Source : National Academy of Sciences

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