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HomeScience and NatureMolecular mechanism of substrate recognition and cleavage by human γ-secretase | Science

Molecular mechanism of substrate recognition and cleavage by human γ-secretase | Science

by News7

Successive cleavages of amyloid precursor protein C-terminal fragment with 99 residues (APP-C99) by γ-secretase result in amyloid-β (Aβ) peptides of varying lengths. Most cleavages have a step size of three residues. To elucidate the underlying mechanism…
Source : ScienceMag

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