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HomeScience and NaturePGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity

PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity

by News7

Proceedings of the National Academy of Sciences, Volume 121, Issue 49, December 2024.
SignificanceOur study provides functional evidence that metabolic reprogramming can directly impact cancer phenotypes and establishes proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α)-induced mitochondrial metabolism as a driver of small …
Source : National Academy of Sciences

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