Symmetry facilitated the evolution of heterospecificity and high-order stoichiometry in vertebrate hemoglobin

Proceedings of the National Academy of Sciences, Volume 122, Issue 4, January 2025.
SignificanceMany molecular complexes are made up of proteins related by gene duplication, but how these assemblies evolve is poorly understood. Using ancestral protein reconstruction and biochemical experiments, we dissected how vertebrate hemoglobin, …
Source : National Academy of Sciences