Targeting DTX2/UFD1-mediated FTO degradation to regulate antitumor immunity

Proceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024.
SignificanceThe m6A RNA demethylase fat mass and obesity-associated protein (FTO) is aberrantly up-regulated in numerous cancers. Here, we report that vitamin E succinate (VES), a widely used dietary supplement and a vitamin E derivative…
Source : National Academy of Sciences