Zscan4 mediates ubiquitination and degradation of the corepressor complex to promote chromatin accessibility in 2C-like cells

Proceedings of the National Academy of Sciences, Volume 121, Issue 52, December 2024.
SignificanceTwo-cell (2C) embryos and 2C-like cells (2CLCs) sporadically arising in mouse embryonic stem cells (mESCs) are associated with increased chromatin accessibility, ensuring the burst expression of transcripts that occur during zygotic genome …
Source : National Academy of Sciences